Non-gradient spatial organisation at tumour–immune interfaces revealed by operator-based analysis

Abstract excerpt

<title>Abstract</title> <p>Most spatial transcriptomics analyses model tissue organisation through scalar gene expression fields and their gradients. This paradigm cannot detect a structurally distinct class of spatial organisation: antisymmetric, non-conservative coupling between biological programmes that is orthogonal to the exact subspace under the discrete Hodge inner product. We introduce a computational op...

Topics

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• Cancer Cells and Metastasis
• Cell Image Analysis Techniques
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

8c8e0ebb-271a-528d-bc2d-62bdfaf038cb

DOI

10.21203/rs.3.rs-10028925/v1