AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity

Abstract excerpt

Identifying functionally important cell states and structure within heterogeneous tumors remains a significant biological and computational challenge. Current clustering- or trajectory-based models are ill-equipped to address the notion that cancer cells reside along a phenotypic continuum. We present Archetypal Analysis network (AAnet), a neural network that learns archetypal states within a phenotypic continuum...

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