Article

Directional deconvolution of spatial conductance proxies resolves prognostic signal cancellation in oral squamous cell carcinoma

2026-05-12

Abstract excerpt

<h4>Background</h4> Tumor cells are increasingly understood as physically connected collectives whose intercellular communication is gated by gap junctions and modulated by microen-vironmental ion fluxes. While spatial transcriptomics provides the geometric substrate for building transcriptomic proxies of bioelectric organization, no robust pipeline currently translates spot-level connectivity features into indep...

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Literature Corpus work: 57f3936d-6da5-5429-b0ab-646f02993e58
DOI: 10.64898/2026.05.08.26351944

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