QUICHE reveals structural definitions of anti-tumor responses in triple negative breast cancer

Abstract excerpt

While recent innovations in spatial biology have driven new insights into how tissue organization is altered in disease, interpreting these datasets in a generalized and scalable fashion remains a challenge. Computational workflows for discovering condition-specific differences in tissue organization typically rely on pairwise comparisons or unsupervised clustering. In many cases, these approaches are computationa...

Topics

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• Biomarkers, Tumor
• Gene Expression Regulation, Neoplastic
• Neoplasms
• Phenotype
• Single-Cell Gene Expression Analysis
• Stomach Neoplasms
• Transcriptome
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

e75ffb97-ac4a-5234-a685-7b003ceacc07

DOI

10.1101/2025.01.06.631548