Article

Morphological Landscape Mapping Decodes Pathological Heterogeneity and Proteomic Programs in HCC

2025-12-02

Abstract excerpt

<h4>Background & Aims</h4> Intratumour heterogeneity (ITH) drives the clinical trajectory of HCC, yet routine pathology relies on global classifications that often mask local architectural diversity. We developed an unsupervised artificial intelligence framework to deconvolute HCC histology into a comprehensive lexicon of morphotypes, link them to in situ proteomic programs, and derive spatial biomarkers for pre...

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Literature Corpus work: d03460ba-50d2-5916-8abb-35fe888aef80
DOI: 10.64898/2025.11.27.25341163

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