Article

Weak supervision of H&E slides reveals systems-level biology and functional states that govern therapeutic resistance

2026-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Precision oncology lacks scalable tools to assess, at the patient level, systems-level tumor microenvironment (TME) programs driving therapeutic resistance. To address this gap, we trained a weakly-supervised deep learning model, using routine H&E slides as input, to derive quantitative activity for therapeutically-relevant TME phenotypes, spanning immune, metabolic, and tumor cell-intrinsic pro...

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Literature Corpus work: ca8d525a-6b3d-5537-9816-aaffd7afa548
DOI: 10.64898/2026.05.05.723013

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