Article

AAnet resolves a continuum of spatially-localized cell states to unveil tumor complexity

2024-05-14

Abstract excerpt

<h4>Summary</h4> Identifying functionally important cell states and structure within a heterogeneous tumor remains a significant biological and computational challenge. Moreover, current clustering or trajectory-based computational models are ill-equipped to address the notion that cancer cells reside along a phenotypic continuum. To address this, we present Archetypal Analysis network (AAnet), a neural network t...

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Literature Corpus work: 2263d915-5916-57e1-b22e-dc728414f33e
DOI: 10.1101/2024.05.11.593705

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