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INSIGHT: Spatially resolved survival modelling from routine histology crosslinked with molecular profiling reveals prognostic epithelial-immune axes in stage II/III colorectal cancer

2026-06-04

Abstract excerpt

<title>Abstract</title> <p>Routine histology contains rich prognostic information in stage II/III colorectal cancer, much of which is embedded in complex spatial tissue organisation. We present INSIGHT, a graph neural network that predicts survival directly from routine histology images. Trained and cross-validated on TCGA (n=342) and SURGEN (n=336), INSIGHT produces patient-level spatially resolved risk scores....

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Literature Corpus work
3405321f-d018-5f5a-8bfb-f05c78b41410
DOI
10.21203/rs.3.rs-8442341/v1
Open publication

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INSIGHT: Spatially resolved survival modelling from routine histology crosslinked with molecular profiling reveals prognostic epithelial-immune axes in stage II/III colorectal cancerDOI 10.21203/rs.3.rs-8442341/v1
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