Article

Spatial Topology Reveals Biologically Distinct Recurrent Motifs in Colorectal Cancer

2026-07-15

Abstract excerpt

Most spatial transcriptomic analyses of solid tumors focus on individual cell states or single-sample spatial domains rather than on recurrent multicellular tissue architectures shared across patients, and typically depend on predefined cell-type annotations or compartment definitions. We developed STORM (Spatial Topology analysis of Recurrent Motifs), an unsupervised graph-attention variational autoencoder that l...

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Literature Corpus work: eb6afd75-5939-5341-b850-91d863c77c9d
DOI: 10.64898/2026.07.09.737584

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