Article

Cryptic leukemia antigens share homology with microbial epitopes and stimulate T-cell responses in healthy donors

2025-12-02

Abstract excerpt

Leukemia cells express cryptic tumor-specific antigens (TSAs) derived from aberrantly transcribed non-exomic genome sequences. These antigens are generally absent from healthy tissues yet shared across patients, making them attractive immunotherapy targets by minimizing on-target/off-tumor toxicity while offering broad applicability. However, their immunogenic potential and the nature of the T-cell repertoire they...

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Literature Corpus work: 8c5271b8-cbae-5a55-8565-927e96708af8
DOI: 10.64898/2025.12.01.691479

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