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Article

Identification of specific T-cell response and T-cell receptor targeting shared neoantigen for acute myeloid leukemia.

Blood cancer journal - 24 Oct 2025

Zhou Weijun, Yu Jinyi, Li Fuyu, Huang Yuting, Du Jingwen, Wu Anqin, Wang Kankan

Abstract excerpt

Accumulation of genetic mutations in malignant myeloid precursor cells leads to an extremely poor prognosis for patients with acute myeloid leukemia (AML). Immunogenic neoantigens recognized by T cell receptor (TCR) can elicit effective immune responses against malignant cells with corresponding somatic mutations. To broaden the range of targeted treatments for AML, in this study, we explored the feasibility of...

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Topics

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Share to Antigens, Neoplasm
Share to DNA Methyltransferase 3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to HLA-A2 Antigen

Share to Leukemia, Myeloid, Acute

Share to Nucleophosmin

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 41136363
DOI: 10.1038/s41408-025-01370-1
PMCID: PMC12552743

Genes

FLT3
NPM1
DNMT3A
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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