Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes.

doi:10.1136/jitc-2023-008645

Article

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes.

Journal for immunotherapy of cancer - 30 May 2024

Levin Noam, Kim Sanghyun P, Marquardt Charles A, Vale Nolan R, Yu Zhiya, Sindiri Sivasish, Gartner Jared J, Parkhurst Maria, Krishna Sri, Lowery Frank J, Zacharakis Nikolaos, Levy Lior, Prickett Todd D, Benzine Tiffany, Ray Satyajit, Masi Robert V, Gasmi Billel, Li Yong, Islam Rafiqul, Bera Alakesh, Goff Stephanie L, Robbins Paul F, Rosenberg Steven A

Abstract excerpt

BACKGROUND: Tumor-infiltrating lymphocytes (TILs) targeting neoantigens can effectively treat a selected set of metastatic solid cancers. However, harnessing TILs for cancer treatments remains challenging because neoantigen-reactive T cells are often rare and exhausted, and ex vivo expansion can further reduce their frequencies. This complicates the identification of neoantigen-reactive T-cell receptors (TCRs)...

Topics

Humans
Lymphocytes, Tumor-Infiltrating
Antigens, Neoplasm
Receptors, Antigen, T-Cell
Mice
Immunologic Memory
Animals
Female

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes.

Abstract excerpt

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