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Article

Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias.

Cell - 26 Jun 2025

Kim Won Jun, Crosse Edie I, De Neef Emma, Etxeberria Inaki, Sabio Erich Y, Wang Eric, Bewersdorf Jan Philipp, Lin Kuan-Ting, Lu Sydney X, Belleville Andrea, Fox Nina, Castro Cynthia, Zhang Pu, Fujino Takeshi, Lewis Jennifer, Rahman Jahan, Zhang Beatrice, Winick Jacob H, Lewis Alexander M, Stanley Robert F, DeWolf Susan, Urben Brigita Meškauskaitė, Takizawa Meril, Krause Tobias, Molina Henrik, Chaligne Ronan, Koppikar Priya, Molldrem Jeffrey, Gigoux Mathieu, Merghoub Taha, Daniyan Anthony, Chandran Smita S, Greenbaum Benjamin D, Klebanoff Christopher A, Bradley Robert K, Abdel-Wahab Omar

Abstract excerpt

Mutations in RNA splicing factors are prevalent across cancers and generate recurrently mis-spliced mRNA isoforms. Here, we identified a series of bona fide neoantigens translated from highly stereotyped splicing alterations promoted by neomorphic, leukemia-associated somatic splicing machinery mutations. We utilized feature-barcoded peptide-major histocompatibility complex (MHC) dextramers to isolate...

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Topics

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Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40273911
DOI: 10.1016/j.cell.2025.03.047
PMCID: PMC12204805

Genes

SRSF2
CLK3
RHOT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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