Article

Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors

2021-06-15

Abstract excerpt

<h4>A bstract </h4> Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive CNS-tumors of infancy and early childhood. Hallmark is the surprisingly simple genome with inactivating mutations or deletions in the SMARCB1 gene as the oncogenic driver. Nevertheless, AT/RTs are infiltrated by immune cells and even clonally expanded T cells. However, it is unclear, which epitopes T-cells might recognize on AT/RT...

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Literature Corpus work: ff0a15ef-8f3a-52c3-86d8-e675fe9260de
DOI: 10.1101/2021.06.11.21258679

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