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Driver mutation landscape of acute myeloid leukemia provides insights for neoantigen-based immunotherapy.

Cancer letters - 28 Feb 2025

Jin Peng, Shen Jie, Zhao Ming, Yu Jinyi, Jin Wen, Jiang Ge, Li Zeyi, He Mengke, Liu Xiaxin, Wu Shishuang, Dong Fangyi, Cao Yuncan, Zhu Hongming, Li Xiaoyang, Wang Xiaoling, Zhang Yunxiang, Jin Zhen, Li Junmin, Wang Kankan

Abstract excerpt

Acute myeloid leukemia (AML) has lagged in benefiting from immunotherapies, primarily due to the scarcity of actionable AML-specific antigens. Driver mutations represent promising immunogenic targets, but a comprehensive characterization of the AML neoantigen landscape and their impact on patient outcomes and the AML immune microenvironment remain unclear. Herein, we conducted matched DNA and RNA sequencing on...

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PMID: 39725148
DOI: 10.1016/j.canlet.2024.217427

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