Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia.

doi:10.1038/s41467-022-29173-z

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Article

Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia.

Nature communications - 11 Apr 2022

Huuhtanen Jani, Bhattacharya Dipabarna, Lönnberg Tapio, Kankainen Matti, Kerr Cassandra, Theodoropoulos Jason, Rajala Hanna, Gurnari Carmelo, Kasanen Tiina, Braun Till, Teramo Antonella, Zambello Renato, Herling Marco, Ishida Fumihiro, Kawakami Toru, Salmi Marko, Loughran Thomas, Maciejewski Jaroslaw P, Lähdesmäki Harri, Kelkka Tiina, Mustjoki Satu

Abstract excerpt

T cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of mature, clonally expanded T cells, where somatic-activating STAT3 mutations are common. Although T-LGLL has been described as a chronic T cell response to an antigen, the function of the non-leukemic immune system in this response is largely uncharacterized. Here, by utilizing single-cell RNA and T cell receptor...

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PMID: 35411050
DOI: 10.1038/s41467-022-29173-z
PMCID: PMC9001660

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