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Article

Cryptic but critical: non-canonical antigens in cancer immunotherapy.

Trends in immunology - 1 Jul 2025

Goncalves Gabriel, Dolcetti Riccardo, Ooi Joshua D, Faridi Pouya

Abstract excerpt

Two recent studies, by Ely et al. and Apavaloaei et al., revealed that non-canonical antigens derived from unmutated, noncoding regions dominate the immunopeptidome of many cancers. Here, we discuss how this challenges conventional mutation-centric immunotherapies and highlight emerging strategies, including cryptic antigen- and TCR-targeted vaccines, as promising new clinically relevant paths in personalised and...

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Identifiers

PMID: 40537348
DOI: 10.1016/j.it.2025.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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