Article

Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease

2025-05-28

Abstract excerpt

<h4>SUMMARY</h4> Allogeneic hematopoietic cell transplantation (alloHCT) is curative for various hematologic diseases but often leads to acute graft-versus-host disease (GVHD), a potentially life-threatening complication. We leverage GVHD as a uniquely tractable disease model to dissect complex T-cell–mediated pathology in 27 alloHCT recipients. We integrate pre-transplant identification of alloreactive T-cells w...

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Identifiers and source

Literature Corpus work: 525eb167-f928-57da-a0f3-4889fb6a62bf
DOI: 10.1101/2025.05.24.655962

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