Article

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

2023-11-16

Abstract excerpt

<title>Abstract</title> <p>T-cell-based immunotherapies hold promise in treating cancer by leveraging the immune system’s recognition of cancer-specific antigens.<sup>1</sup> However, their efficacy is often limited in tumors with fewer somatic mutations and significant intratumoral heterogeneity, such as glioblastoma.<sup>2–5</sup> Here we introduce a previously uncharacterized class of tumor-wide and public neo...

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Literature Corpus work: 81f471dc-d375-5b40-8348-f542244e9803
DOI: 10.21203/rs.3.rs-3496988/v1

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