Article

CRISPR screens in 3D assembloids reveal disease genes associated with human interneuron development

2022-09-06

Abstract excerpt

The assembly of cortical circuits involves the generation and migration of cortical interneurons from the ventral to the dorsal forebrain, which has been challenging to study in humans as these processes take place at inaccessible stages of late gestation and early postnatal development. Autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDDs) have been associated with abnormal cortical interne...

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Literature Corpus work: 8c20980e-e6ad-5ea6-bbe9-80980155de91
DOI: 10.1101/2022.09.06.506845

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