Article

Single-cell brain organoid screening identifies developmental defects in autism

2022-09-15

Abstract excerpt

Development of the human brain involves processes that are not seen in many other species, but can contribute to neurodevelopmental disorders (1–4). Cerebral organoids can be used to investigate neurodevelopmental disorders in a human context but are limited by variability and low throughput. We have developed the CRISPR-human organoids-scRNA-seq (CHOOSE) system that utilizes verified pairs of gRNAs, inducible CRI...

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Literature Corpus work: 50e61c32-f959-5601-82ca-e1ffd7de6fd9
DOI: 10.1101/2022.09.15.508118

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