Article

<i>In vivo</i> Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genes

2019-10-07

Abstract excerpt

The thousands of disease risk genes and loci identified through human genetic studies far outstrip our current capacity to systematically study their functions. New experimental approaches are needed for functional investigations of large panels of genes in a biologically relevant context. Here, we developed a scalable genetic screen approach, in vivo Perturb-Seq, and applied this method to the functional evaluat...

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Identifiers and source

Literature Corpus work: 82218797-e5e3-58dc-a700-a4d386c6db8c
DOI: 10.1101/791525

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