Article

Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoids

2020-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Neuropsychiatric and neurodevelopmental disorders have been particularly challenging to study using animal models, and recently, human-derived cerebral organoids demonstrate great promise for discovering molecular processes that are important in these disorders. However, several challenges remain in achieving robust phenotyping to discover cell type specific genes. We perform RNA sequencing on 7...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1c982060-2f64-52ce-876e-1efdbac956e3
DOI: 10.1101/2020.11.15.375386

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoidsDOI 10.1101/2020.11.15.375386Read

Data integration of bulk and single-cell transcriptomics from cerebral organoids and post-mortem brains to identify cell types and cell type specific driver genes in autismSemantic proximity Read

oFlowSeq: a quantitative approach to identify protein coding mutations affecting cell type enrichment using mosaic CRISPR-Cas9 edited cerebral organoids.Semantic proximity Read

oFlowSeq: A multiplexed quantitative approach to identify genes affecting cell type enrichment using mosaic CRISPR-Cas9 edited cerebral organoidsSemantic proximity Read

Patient brain organoids identify a link between the 16p11.2 copy number variant and the <i>RBFOX1</i> geneSemantic proximity Read

Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of <i>CHD8</i> heterozygous cerebral organoidsSemantic proximity Read

Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and the RBFOX1 Gene.Semantic proximity Read

Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genesSemantic proximity Read

Single-cell brain organoid screening identifies developmental defects in autismSemantic proximity Read

Cortical Organoids Model Early Brain Development Disrupted by 16p11.2 Copy Number Variants in AutismSemantic proximity Read

Copy Number Variation at 16p11.2 Imparts Transcriptional Alterations in Neural Development in an hiPSC-derived Model of CorticogenesisSemantic proximity Read

Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolutionSemantic proximity Read

A phenotypic brain organoid atlas for neurodevelopmental disordersSemantic proximity Read