Article

Data integration of bulk and single-cell transcriptomics from cerebral organoids and post-mortem brains to identify cell types and cell type specific driver genes in autism

2020-12-02

Abstract excerpt

<title>Abstract</title> Human-derived cerebral organoids demonstrate great promise for identifying cell types and cell type specific molecular processes perturbed by genetic variants associated with neuropsychiatric and neurodevelopmental disorders, which are notoriously challenging to study using animal models. However, considerable challenges remain in achieving robust, scalable and generalizable phenotyping...

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Literature Corpus work: 758be1de-a7e6-55cc-aebe-c34093e7fda3
DOI: 10.21203/rs.3.rs-113869/v1

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