Article

CRISPR-Enabled Functional Genomics in hPSC-Derived Neural Models for Autism Spectrum Disorder

2025-11-26

Abstract excerpt

Autism Spectrum Disorder (ASD) is a genetically heterogeneous neurodevelopmental condition driven by rare de novo variants, copy number variations, and polygenic risk. SFARI-curated genes show high mutational constraint and enriched expression in cortical neurons and glia. This review highlights recent advances in CRISPR-based functional genomics using human pluripotent stem cells and induced pluripotent stem cell...

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Literature Corpus work: 353d6240-face-5a13-866f-34b566d1a045
DOI: 10.20944/preprints202511.1997.v1

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