Article

Cortical assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects

2024-11-26

Abstract excerpt

Disruption of parvalbumin positive (PVALB+) cortical interneurons is implicated in the pathogenesis of schizophrenia. However, how these defects emerge during brain development remains poorly understood. The protracted maturation of these cells during postnatal life has made their derivation from human pluripotent stem cells (hPSCs) extremely difficult, precluding hPSC-based disease modeling of their role in neuro...

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Literature Corpus work: ccad6c97-893f-5819-a4b8-0ff16af31381
DOI: 10.1101/2024.11.26.624368

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Cortical assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defectsDOI 10.1101/2024.11.26.624368Read

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