Article

A novel role for SHARPIN in amyloid-β phagocytosis and inflammation by peripheral blood-derived macrophages in Alzheimer’s disease

2019-08-19

Abstract excerpt

<h4>INTRODUCTION</h4> Defective immune cell-mediated clearance of amyloid-beta (Aβ) and Aβ-associated inflammatory activation of immune cells are key contributors of Aβ accumulation and neurodegeneration in Alzheimer’s disease (AD), however, the underlying mechanisms remain elusive. <h4>METHODS</h4> Differentiated THP-1 cells treated with Aβ and AD patient-derived macrophages were used as in-vitro model. The ro...

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Literature Corpus work: 8c0b62a3-f2ed-5e9f-a915-9204e462c1e3
DOI: 10.1101/732164

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