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Article

TREM1 facilitates microglial phagocytosis of amyloid beta.

Acta neuropathologica - 1 Nov 2016

Jiang Teng, Zhang Ying-Dong, Gao Qing, Zhou Jun-Shan, Zhu Xi-Chen, Lu Huan, Shi Jian-Quan, Tan Lan, Chen Qi, Yu Jin-Tai

Abstract excerpt

As the most common type of neurodegenerative disease, Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptide (Aβ) within the brain. Triggering receptor expressed on myeloid cells (TREM) 1 is an immune receptor expressed by mononuclear phagocytes including monocytes and microglia, coupling with TYRO protein tyrosine kinase binding protein to regulate immune reactions. Emerging evidence...

Read the complete abstract on PubMed

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27670763
DOI: 10.1007/s00401-016-1622-5

Genes

TREM1
APP
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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