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MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease

12 Dec 2015

Abstract excerpt

INTRODUCTION: Mononuclear phagocytes play a critical role during Alzheimer's disease (AD) pathogenesis due to their contribution to innate immune responses and amyloid beta (Aβ) clearance mechanisms. METHODS: Blood-derived monocytes (BDMs) and monocyte-derived macrophages (MDMs) were isolated from blood of AD, mild cognitive impairment (MCI) patients, and age-matched healthy controls for molecular and phenotypic...

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PMID: 27239545
DOI: 10.1016/j.dadm.2015.11.004

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