The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide.

Abstract excerpt

BACKGROUND: The toxicity of amyloid-β (Aβ) peptide present in the brain of Alzheimer's disease (AD) patients is thought to be mediated via the increased secretion of pro-inflammatory mediators, which can lead to neuronal dysfunction and cell death. In addition, we have previously shown that inflammation can affect Aβ generation. More recently, we have reported that in vitro administration of the anti-inflammatory...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid beta-Peptides
• Share to Amyloid beta-Protein Precursor