Article

Perivascular SPP1 Mediates Microglial Engulfment of Synapses in Alzheimer’s Disease Models

2022-04-05

Abstract excerpt

<h4>Summary</h4> Microglia are phagocytes of the brain parenchyma, where they interact with neurons to engulf synapses in a context-dependent manner. Genetic studies in Alzheimer’s disease (AD) highlight dysfunctional phagocytic signaling in myeloid cells as disease-associated pathway. In AD models, there is a region-specific reactivation of microglia-synapse phagocytosis involving complement; however, what drive...

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Literature Corpus work: bb69d859-4c95-56f9-9aac-9ea6cfc57bc7
DOI: 10.1101/2022.04.04.486547

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