Article
Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications
1 Aug 2014
Abstract excerpt
In healthy individuals, billions of cells die by apoptosis every day. Removal of the dead cells by phagocytosis (a process called efferocytosis) must be efficient to prevent secondary necrosis and the consequent release of pro-inflammatory cell contents that damages the tissue environment and provokes autoimmunity. In addition, detection and removal of apoptotic cells generally induces an anti-inflammatory...
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