Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

9 Mar 2023

Abstract excerpt

BACKGROUND: Persistent inflammatory response in the brain can lead to tissue damage and neurodegeneration. In Alzheimer's disease (AD), there is an aberrant activation of inflammasomes, molecular platforms that drive inflammation through caspase-1-mediated proteolytic cleavage of proinflammatory cytokines and gasdermin D (GSDMD), the executor of pyroptosis. However, the mechanisms underlying the sustained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol and Lipid Metabolism
Share to Inflammasome and immune disorders
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36895045
DOI: 10.1186/s40035-023-00343-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosisPMID 36895045Read ↗

Integrated stress response associated with dark microglia promotes microglial lipogenesis and contributes to neurodegenerationSemantic proximity Read ↗

Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.Semantic proximity Read ↗

Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s DiseaseSemantic proximity Read ↗

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentialsSemantic proximity Read ↗

Microglial ApoD Induced NLRC4 Inflammasome Activation Promotes Alzheimer’s Disease ProgressionSemantic proximity Read ↗

Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer’s Disease Revealed by Pharmacological and Genetic Microglial DepletionSemantic proximity Read ↗

Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation.Semantic proximity Read ↗

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease.Semantic proximity Read ↗

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brainSemantic proximity Read ↗

Systemic Inflammasome Activation and Pyroptosis Associate with the Progression of Alzheimer’s DiseaseSemantic proximity Read ↗

Diesel exhaust particles disrupt mouse and human iPSC-derived microglial function and Amyloid-β clearance in Alzheimer’s disease modelsSemantic proximity Read ↗

Modulation of mitochondria-ER contacts decrease inflammasome formation and restores amyloid β-peptide phagocytosis in adult mouse microgliaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.