Back to search

Article

Beyond the Blood-Brain Barrier: Peripheral Immune Signaling and Metabolic Dysfunction as Regulators of Microglial Phagocytosis in Dementia, A Systematic Review

2026-08-19

Abstract excerpt

Alzheimer’s disease (AD) is one of the most prevalent causes of dementia, with both genetic and environmental factors influencing its progression. The role of phagocytosis and its relationship to AD-associated neuroinflammation has recently garnered considerable attention in the field. For this systematic review, Scopus and PubMed databases were searched to identify studies examining how peripheral immune signalin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c52688a8-963c-564e-bd58-39c406ca61e8
DOI
10.20944/preprints202608.1289.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Beyond the Blood-Brain Barrier: Peripheral Immune Signaling and Metabolic Dysfunction as Regulators of Microglial Phagocytosis in Dementia, A Systematic ReviewDOI 10.20944/preprints202608.1289.v1
Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentialsSemantic proximity
Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer’s Disease GeneticsSemantic proximity
Hypothesis: Modulation of microglial phenotype in Alzheimer's disease drives neurodegeneration.Semantic proximity
The role of monocytes and macrophages in the progression of Alzheimer’s diseaseSemantic proximity
Microglia Phenotypes in Aging and Neurodegenerative Diseases.Semantic proximity
MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's diseaseSemantic proximity
The role of macrophage plasticity in neurodegenerative diseasesSemantic proximity
The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progressionSemantic proximity
Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?Semantic proximity
Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer’s DiseaseSemantic proximity
Autophagy and Microglia: Novel Partners in Neurodegeneration and AgingSemantic proximity
Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic diseaseSemantic proximity
Select a neighboring publication to make it the new centre.