Article
Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort.
Translational psychiatry - 9 Sept 2020
Grama Steluta, Willcocks Isabella, Hubert John J, Pardiñas Antonio F, Legge Sophie E, Bracher-Smith Matthew, Menzies Georgina E, Hall Lynsey S, Pocklington Andrew J, Anney Richard J L, Bray Nicholas J, Escott-Price Valentina, Caseras Xavier
Abstract excerpt
Research has shown differences in subcortical brain volumes between participants with schizophrenia and healthy controls. However, none of these differences have been found to associate with schizophrenia polygenic risk. Here, in a large sample (n = 14,701) of unaffected participants from the UK Biobank, we test whether schizophrenia polygenic risk scores (PRS) limited to specific gene-sets predict subcortical...
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