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Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk

10 Apr 2019

Abstract excerpt

Importance: Between-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group...

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PMID: 30969333
DOI: 10.1001/jamapsychiatry.2019.0257

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