Article
Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology.
Biological psychiatry - 15 Aug 2022
van der Meer Dennis, Shadrin Alexey A, O'Connell Kevin, Bettella Francesco, Djurovic Srdjan, Wolfers Thomas, Alnæs Dag, Agartz Ingrid, Smeland Olav B, Melle Ingrid, Sánchez Jennifer Monereo, Linden David E J, Dale Anders M, Westlye Lars T, Andreassen Ole A, Frei Oleksandr, Kaufmann Tobias
Abstract excerpt
BACKGROUND: Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite low genetic correlations. Through the use of analytical methods that allow for mixed directions of effects, this overlap may be leveraged to improve our understanding of underlying mechanisms of...
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