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Article

Derivation and utility of schizophrenia polygenic risk associated multimodal MRI frontotemporal network.

Nature communications - 22 Aug 2022

Qi Shile, Sui Jing, Pearlson Godfrey, Bustillo Juan, Perrone-Bizzozero Nora I, Kochunov Peter, Turner Jessica A, Fu Zening, Shao Wei, Jiang Rongtao, Yang Xiao, Liu Jingyu, Du Yuhui, Chen Jiayu, Zhang Daoqiang, Calhoun Vince D

Abstract excerpt

Schizophrenia is a highly heritable psychiatric disorder characterized by widespread functional and structural brain abnormalities. However, previous association studies between MRI and polygenic risk were mostly ROI-based single modality analyses, rather than identifying brain-based multimodal predictive biomarkers. Based on schizophrenia polygenic risk scores (PRS) from healthy white people within the UK...

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Identifiers

PMID: 35995794
DOI: 10.1038/s41467-022-32513-8
PMCID: PMC9395379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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