Article
The genetic relationships between brain structure and schizophrenia.
Nature communications - 28 Nov 2023
Stauffer Eva-Maria, Bethlehem Richard A I, Dorfschmidt Lena, Won Hyejung, Warrier Varun, Bullmore Edward T
Abstract excerpt
Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain structure but it has been unclear which genes are associated with both schizophrenia and cortical phenotypes. We accessed genome-wide association studies (GWAS) of schizophrenia (N = 69,369 cases; 236,642 controls), and of three magnetic resonance imaging (MRI) metrics (surface area, cortical thickness, neurite density index)...
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