Article

Chemical genetic interaction linking eIF5A hypusination and mitochondrial integrity

2023-12-20

Abstract excerpt

The eukaryotic translation factor eIF5A plays an important role in translation elongation, especially across stretches of prolines and charged amino acids, and in translation termination. eIF5A undergoes hypusination, a post-translational modification unique to this protein, although the role of hypusination in the function of eIF5A remains elusive. Here, we investigated the cellular defects induced by the hypusin...

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Literature Corpus work: 8bb6dbc2-effc-57da-9be3-dda627543dfd
DOI: 10.1101/2023.12.20.571781

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