Article

A novel viral protein translation mechanism reveals mitochondria as a target for antiviral drug development

2020-10-19

Abstract excerpt

The ongoing Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic has acutely highlighted the need to identify new treatment strategies for viral infections. Here we present a pivotal molecular mechanism of viral protein translation that relies on the mitochondrial translation machinery. We found that rare codons such as Leu-TTA are highly enriched in many viruses, including SARS-CoV-2, and these c...

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Literature Corpus work: 4f9fb5e0-30ed-539b-ae22-8e24466216b5
DOI: 10.1101/2020.10.19.344713

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