Article

RNF25 restrains GCN2 hyperactivation to sustain protein synthesis and cell proliferation in response to RNA damage

2026-03-24

Abstract excerpt

Regulation of protein synthesis is essential for maintaining cellular homeostasis during stress. The integrated stress response (ISR) is a conserved signaling pathway that modulates global mRNA translation through four eIF2α kinases—GCN2, PKR, PERK, and HRI. However, how these kinases are selectively activated and tuned to distinct stress signals to direct appropriate cell fate decisions remains poorly understood....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c133c80-4da5-5847-814d-d6e089511d83
DOI: 10.64898/2026.03.21.713335

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNF25 restrains GCN2 hyperactivation to sustain protein synthesis and cell proliferation in response to RNA damageDOI 10.64898/2026.03.21.713335Read

IGHMBP2 deletion suppresses translation and activates the integrated stress responseSemantic proximity Read

Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathwaySemantic proximity Read

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient StressSemantic proximity Read

Sumoylation of eIF4A2 affects stress granule formation.Semantic proximity Read

Transcriptional profile of ribosome-associated quality control components and their associated phenotypes in mammalian cellsSemantic proximity Read

<i>In vivo</i> single-cell CRISPR screening for microproteins identifies a critical ribosomal componentSemantic proximity Read

Decoding RNA Metabolism by RNA-linked CRISPR Screening in Human CellsSemantic proximity Read

Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation.Semantic proximity Read

p53 at the crossroad of DNA replication and ribosome biogenesis stress pathwaysSemantic proximity Read

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated transcriptome in human cellsSemantic proximity Read

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasisSemantic proximity Read

Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer.Semantic proximity Read