Article
Regulation of EIF5A and hypusination by p53 determines colorectal cancer cell fitness.
Cancer letters - 28 Sept 2026
Gobert Alain P, Hawkins Caroline V, Asim Mohammad, Barry Daniel P, Delgado Alberto G, Tyree Regina N, Carson Kate S, Kahlon Nikhil P S, Ciampa Mark V, Rose Kristie L, Patel Purvi, Pusapati Ganesh V, Rohatgi Rajat, Yu Wang, Zhao Shilin, Coburn Lori A, Blanca Piazuelo M, Wilson Keith T
Abstract excerpt
Hypusination of eukaryotic translation initiation factor 5 A (EIF5A) by the enzyme deoxyhypusine synthase (DHPS) is a mechanism of regulation of translation that plays a role in cell proliferation. Herein, we assessed the role of hypusination in established colorectal cancer (CRC). Using molecular and biochemical approaches in established CRC cell lines and human colon organoids, we found that the tumor...
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