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Article

The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.

The Journal of cell biology - 29 Jun 2009

Patel Prajal H, Costa-Mattioli Mauro, Schulze Karen L, Bellen Hugo J

Abstract excerpt

Hypusination is a unique posttranslational modification by which lysine is transformed into the atypical amino acid hypusine. eIF5A (eukaryotic initiation factor 5A) is the only known protein to contain hypusine. In this study, we describe the identification and characterization of nero, the Drosophila melanogaster deoxyhypusine hydroxylase (DOHH) homologue. nero mutations affect cell and organ size,...

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Source

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Identifiers

PMID: 19546244
DOI: 10.1083/jcb.200904161
PMCID: PMC2712966

Genes

DOHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.PMID 19546244Read ↗

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Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification.Semantic proximity Read ↗

Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.Semantic proximity Read ↗

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