Article
Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.
Molecular biology of the cell - 1 Jul 2010
Taylor Eleanor J, Campbell Susan G, Griffiths Christian D, Reid Peter J, Slaven John W, Harrison Richard J, Sims Paul F G, Pavitt Graham D, Delneri Daniela, Ashe Mark P
Abstract excerpt
Recycling of eIF2-GDP to the GTP-bound form constitutes a core essential, regulated step in eukaryotic translation. This reaction is mediated by eIF2B, a heteropentameric factor with important links to human disease. eIF2 in the GTP-bound form binds to methionyl initiator tRNA to form a ternary complex, and the levels of this ternary complex can be a critical determinant of the rate of protein synthesis. Here we...
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