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Article

Hypusine-containing protein eIF5A promotes translation elongation.

Nature - 7 May 2009

Saini Preeti, Eyler Daniel E, Green Rachel, Dever Thomas E

Abstract excerpt

Translation elongation factors facilitate protein synthesis by the ribosome. Previous studies identified two universally conserved translation elongation factors, EF-Tu in bacteria (known as eEF1A in eukaryotes) and EF-G (eEF2), which deliver aminoacyl-tRNAs to the ribosome and promote ribosomal translocation, respectively. The factor eIF5A (encoded by HYP2 and ANB1 in Saccharomyces cerevisiae), the sole protein...

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Identifiers

PMID: 19424157
DOI: 10.1038/nature08034
PMCID: PMC3140696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Hypusine-containing protein eIF5A promotes translation elongation.PMID 19424157Read ↗

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome.Semantic proximity Read ↗

Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex.Semantic proximity Read ↗

Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification.Semantic proximity Read ↗

eIF5A has a function in the elongation step of translation in yeast.Semantic proximity Read ↗

Structural modeling and mutational analysis of yeast eukaryotic translation initiation factor 5A reveal new critical residues and reinforce its involvement in protein synthesis.Semantic proximity Read ↗

Eukaryotic translation initiation factor 5A and its hypusination play an important role in proliferation and differentiation of the human enteric protozoan parasite <i>Entamoeba histolytica</i>Semantic proximity Read ↗

Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2.Semantic proximity Read ↗

Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway.Semantic proximity Read ↗

eIF5A coordinates the transcription and translation of its target genesSemantic proximity Read ↗

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.Semantic proximity Read ↗

Chemical genetic interaction linking eIF5A hypusination and mitochondrial integritySemantic proximity Read ↗

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