Article

Epigenome-wide study uncovers tau pathology-driven changes of chromatin organization in the aging human brain

2018-02-28

Abstract excerpt

<h4>Summary</h4> Accumulation of tau and amyloid-β are two pathologic hallmarks of Alzheimer’s disease (AD). Here, we conducted an epigenome-wide association study using the H3K9 acetylation (H3K9Ac) mark in 669 aged human prefrontal cortices: in contrast to amyloid-β, tau protein burden had a broad effect on the epigenome, affecting 5,590 out of 26,384 H3K9Ac domains. Tau-related alterations aggregated in large...

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Literature Corpus work: 8bb3b82f-2048-5190-af55-cdfbf2b62f0a
DOI: 10.1101/273789

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