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Phospho-Tau and Chromatin Landscapes in Early and Late Alzheimer’s Disease

24 Sept 2021

Abstract excerpt

Cellular identity is determined through complex patterns of gene expression. Chromatin, the dynamic structure containing genetic information, is regulated through epigenetic modulators, mainly by the histone code. One of the main challenges for the cell is maintaining functionality and identity, despite the accumulation of DNA damage throughout the aging process. Replicative cells can remain in a senescent state...

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PMID: 34638632
DOI: 10.3390/ijms221910283

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