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Epigenetic signatures of regional tau pathology and cognition in the aging and pathological brain

2024-11-12

Abstract excerpt

<h4>ABSTRACT</h4> Primary age-related tauopathy (PART) and Alzheimer’s disease (AD) share hippocampal phospho-tau (p-tau) pathology but differ in ß-amyloid burden and degree of p-tau severity and spread. Thus, PART provides a human model to understand the mechanisms of age and amyloid-independent modifiers of p-tau. Given the dynamics of DNA methylation over the lifespan, we (1) performed an epigenome-wide associ...

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Literature Corpus work
2cee40c7-8eca-5fa1-a443-b1b260461e49
DOI
10.1101/2024.11.07.24316933
Open publication

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Epigenetic signatures of regional tau pathology and cognition in the aging and pathological brainDOI 10.1101/2024.11.07.24316933
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