Article

Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer’s Disease

2025-09-30

Abstract excerpt

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, yet the molecular mechanisms underlying its region– and cell-type-specific pathogenesis remain poorly defined. Here, we generated a large-scale, single-cell multi-omic atlas—integrating DNA methylation and 3D genome architecture—from postmortem brain tissue of matched AD patients and cognitively normal controls. Samples were collected from thr...

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Literature Corpus work: 9e23f171-cddb-59c6-81d5-c5b64389c844
DOI: 10.1101/2025.09.29.678849

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